PERK Reprograms Hematopoietic Progenitor Cells to Direct Tumor-Promoting Myelopoiesis in the Spleen

Scientists found that PKR-like endoplasmic reticulum kinase (PERK) mediated HSPC reprogramming into committed MDSC precursors in the spleen via PERK–ATF4–C/EBPβ signaling.