Deubiquitinase CYLD Acts as a Negative Regulator of Dopamine Neuron Survival in Parkinson’s Disease

Researchers identified deubiquitinase cylindromatosis (CYLD) as a negative regulator of dopamine neuron survival, and inhibition of CYLD could potentially be beneficial in Parkinson’s disease by lowering parkin interacting substrate ZNF746 levels and promoting mitochondrial biogenesis.