GPR177 in A-Fiber Sensory Neurons Drives Diabetic Neuropathic Pain via WNT-Mediated TRPV1 Activation

Scientists reported that the orphan G protein–coupled receptor 177 (GPR177) in A-fiber neurons drove diabetic neuropathic pain via WNT5a-mediated activation of transient receptor potential vanilloid receptor-1 (TRPV1) ion channel.