[GSK Plc.] GSK plc and Boston Pharmaceuticals announced that they have entered into an agreement under which GSK will acquire Boston Pharmaceuticals’ lead asset, efimosfermin alfa.

[European Respiratory Journal] Expression and localization of cGAS, cytokines, and type 1 interferons were evaluated in SSc-ILD lung tissues, bronchoalveolar lavage (BAL), and isolated lung fibroblasts.

[Hepatology] Hepatic extracellular matrix protein 1 (ECM1) expression was evaluated and found to be significantly reduced in liver samples from patients with metabolic dysfunction-associated steatohepatitis, and in four established MASH mouse models.

[Nature Reviews Bioengineering] Investigators explore how the CRISPR–Cas toolbox can be engineered to kill or modify specific bacteria.

[Cell] Researchers presented an ESC-derived 3D model of the post-gastrulation amnion, post-gastrulation amnioids, that faithfully recapitulates extra-embryonic development up to four weeks post-fertilization, closely mimicking the functional traits of the human amniotic sac.

[Brain] Scientists first quantified a high expression level of astrocytic mGluR5 in the hippocampus of Alzheimer’s disease brains and demonstrated that the expression of astrocytic mGluR5 was positively correlated with Alzheimer’s disease progression in both humans and mice.

[Cancer Cell] Genetically engineered mice mimicking heterozygous elongator acetyltransferase complex subunit 1 (Elp1) loss-of-function seen in affected germline carriers exhibit hallmark features of premalignancy in cerebellar granule neuron progenitors.

[Nature Metabolism] Using a model of unilateral exercise in male participants and deep phosphoproteomic analyses, researchers find that a prolonged activation of a signaling pathway involving MKK3b/6, p38, MK2 and mTORC1 occurs specifically in response to resistance exercise.

[Biofabrication] Scientists examined how scaffold fiber orientation influences mechanical properties and cellular behaviour by utilising melt electrowriting as a high-resolution 3D printing technique that combines aspects of electrospinning and melt based polymer deposition.

[Proceedings of The National Academy of Sciences of The United States of America] Researchers combined experimental data and in silico modeling to dissect the contributions of different components in the mantATP chasing signal.

[Cardiovascular Research] Transcriptome dataset and human atherosclerotic samples were used to determine nuclear factor erythroid 2-related factor 3 (Nrf3) expression levels. Global and vascular smooth muscle cell (VSMC)-specific Nrf3 knockout mice were used to assess the role of Nrf3 in VSMC function and injury-induced neointimal hyperplasia.

Researchers showed that adenosine suppresses anti-cancer T cell responses following uptake into activated T cells by equilibrative nucleoside transporter 1 (ENT1) and inhibition of de novo...