[Nature Communications] Scientists showed that during somatic embryogenesis induced by overexpressing the totipotency-regulating transcription factor LEAFY COTYLEDON2 (LEC2) in Arabidopsis, CHH hypermethylation is deposited by the LEC2-activated RNA-directed DNA methylation pathway.

[Biological Research] Researchers disturbed the nicotinamide phosphoribosyltransferase (NAMPT) activity and employed immunofluorescence staining and live cell imaging to explore its roles during early embryo development.

[Circulation] Cardiomyocyte-specific N6-adenosine-methyltransferase-like 3 (METTL3) knockout mice and their wild-type littermates were subjected to either chow diet or high-fat diet feeding and injection of streptozotocin to induce diabetic cardiomyopathy.

[Circulation] Dual specificity phosphatase 14 (Dusp14) knockout mice were generated, and adeno-associated virus–mediated cardiomyocyte-specific overexpression of Dusp14 was used in combination with related cellular experiments to investigate the protective effects of Dusp14 on hypothyroidism-induced heart failure.

[Nature Communications] The authors demonstrated that the let-7 miRNA family plays a homeostatic role in alveolar type 2 (AT2) quiescence by preventing the uncontrolled accumulation of AT2 transitional cells and promoting AT1 differentiation.

[Gut] Researchers used genetically engineered mouse models with liver-specific deletion of tumour suppressors Rb and p53 together with activation of oncogenic Kras to investigate the cell of origin in intrahepatic cholangiocarcinoma.

[Small] Acid-sensitive responsive CaMnCO₃ nanoparticles were developed that simultaneously mitigate tumor microenvironment acidosis and hypoxia.

[Science] Investigators discovered that the antidepressant effects of ketamine can be prolonged by manipulations of the signal transduction cascade involving extracellular signal–regulated kinase (ERK).

[Acta Pharmacologica Sinica] The authors investigated the effect of deleting the translin/trax microRNA-degrading enzyme on cocaine-induced behavioral responses in mice.

[Cell Reports] Investigators developed a human iPSC-derived hepatic organoid culture system that effectively retains hepatic characteristics long term.

[Genprex, Inc. ] Genprex, Inc. announced that following the recent completion of its two-year Sponsored Research Agreement (SRA) with the University of Pittsburgh of the Commonwealth System of Higher Education to study T1D and T2D, the parties have entered into a new SRA to study GPX-002 in T1D and T2D in animal models.

[Aging-Us] Researchers measured changes in blood glucose and insulin levels following oxytocin (Oxt) administration in wild-type and Oxt receptor knockout mice.