CAFs Shape Myeloid-Derived Suppressor Cells to Promote Stemness of Intrahepatic Cholangiocarcinoma via 5-Lipoxygenase

Researchers investigated whether and how cancer-associated fibroblasts (CAFs) regulated myeloid-derived suppressor cells function to enhance cancer stemness, the driving force of the cancer aggressiveness and chemotherapy refractoriness, in highly desmoplastic intrahepatic cholangiocarcinoma.