Functional Characterization of T2D-Associated SNP Effects on Baseline and ER Stress-Responsive β Cell Transcriptional Activation

Using massively parallel reporter assays, scientists tested the cis-regulatory effects of single nucleotide polymorphisms associated with type 2 diabetes (T2D) and altered in vivo islet chromatin accessibility in MIN6 β cells under steady state and pathophysiologic endoplasmic reticulum stress conditions.