COMMD10 Is Critical for Kupffer Cell Survival and Controls Ly6Chi Monocyte Differentiation and Inflammation in the Injured Liver

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Copper metabolism MURR1 domain (COMMD10) deficiency in Kupffer cells and in other tissue-resident macrophages impedes their homeostatic survival, leading to their continuous replacement by Ly6Chi monocytes.
[Cell Reports]

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AbstractGraphical Abstract