BIX01294 Inhibits EGFR Signaling in EGFR-Mutant Lung Adenocarcinoma Cells through a BCKDHA-Mediated Reduction in the EGFR Level

The authors reported that BIX01294 (BIX) induced apoptotic cell death in EGFR-mutant NSCLC cells but not in their wild-type counterparts. Treatment with BIX resulted in a significant reduction in the EGFR level and inhibition of EGFR signaling only in EGFR-mutant NSCLC cells, leading to apoptosis.