[Brain] To evaluate how modulation of SUMOylation might influence functional measures of neuronal activity in Huntington’s disease cells in vitro, scientists utilized primary neuronal cultures from R6/2 transgenic and non-transgenic.

[Molecular Psychiatry] The authors argue that leveraging pleiotropic effects will provide opportunities to discover novel drug targets and identify more effective treatments for psychiatric disorders by targeting a common mechanism rather than treating each disease separately.

[Genome Biology] Researchers applied a novel computational workflow to a spatiotemporally profiled glioblastoma xenograft cohort, leveraging the ability to distinguish human tumor from mouse tumor microenvironment to overcome previous limitations in the analysis of diffuse invasion.

[Small] Investigators fabricated sub-10nm multifunctional dual-carbon dots composites (ERCD) with photo-propelled nanomotor behavior. Near-infrared-activated ERCD-1 imaged Aβ plaques in vivo and prolonged nematode lifespan by six sdays at 2 µg mL-1.

[Nature Communications] Scientists reported that Med15 was expressed during mouse β-cell development and maturation. Knockout of Med15 in mouse β-cells caused defects in β-cell maturation without affecting β-cell mass or insulin expression.

[Cell Death & Disease] After establishing gemcitabine-resistant cell lines and collecting pancreatic cancer and adjacent normal tissues from gemcitabine-treated patients, investigators observed that circ-NEK6 (cNEK6) was highly expressed in the peripheral blood and tumor tissues of patients and xenografts with gemcitabine-resistant PDAC.

[Oncogenesis] In vitro and in vivo studies revealed a novel mechanistic axis, demonstrating the involvement of inositol polyphosphate 4-phosphatase type II B in ubiquitin-specific protease 10-mediated colorectal cancer modulation.

[Proceedings of The National Academy of Sciences of The United States of America] Researchers reported that tripartite motif-containing protein 21 (TRIM21) functioned as a target of extracellular signal-regulated kinase 2 in KRAS-mutant colorectal cancer, contributing to regorafenib therapy resistance.

[Developmental Cell] Using human induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) from patients with age-related macular degeneration, the authors demonstrated that reduced activity of RPE-secreted matrix metalloproteinase 2 contributed to drusen in multiple maculopathies in a genotype-agnostic manner.

[Gut] Patients were randomized during endoscopic retrograde cholangiopancreatography to receive either endoscopic sphincterotomy or no sphincterotomy prior to fully covered self-expandable metal stent placement.

[Advanced Materials Interfaces] The authors provide a materials science perspective on polyacrylamide (PAAm) material properties, fabrication, and modification strategies relevant to cell studies, emphasized toward dynamic PAAm hydrogels with on-demand control over hydrogel properties.

[Signal Transduction and Targeted Therapy] Scientists emphasize the dynamic and intricate systematic alterations that occur as cancer progresses, illustrate the immunological landscape of organ-specific pre-metastatic niche creation, and deepen our understanding of treatment modalities pertinent to metastasis.