[Signal Transduction and Targeted Therapy] Scientists summarize the underlying mechanism, screening, diagnosis, prevention, and treatment of type 2 diabetes, especially regarding the personalized selection of hypoglycemic agents and holistic management based on the concept of metabolic syndrome-related target organ damage.

[Molecular Cancer] The impact of circPIAS1-108aa on the ferroptosis process of melanoma cells was studied through glutathione, malondialdehyde, and C11-BODIPY staining assays. Proliferation changes in melanoma cells were assessed using cell counting Kit-8, EdU, and colony formation assays.

[Journal of Experimental & Clinical Cancer Research] CRISRPcas9 was used to knock out IRF1 and IRF2 genes in human and mouse melanoma cells and the resulting phenotypes were analyzed in vitro and in vivo.

[Journal For Immunotherapy of Cancer] Researchers investigated the binding between PD-1, pembrolizumab, and galectin-3 (Gal-3) by surface plasmon resonance and cryogenic electron microscopy. The function was studied in in vitro cultures and soluble levels of both PD-1 and Gal-3 were measured in metastatic melanoma patients, treated with pembrolizumab.

[Cell Death & Disease] Scientists discovered that lipid peroxidation promoted the formation of lipid rafts in the membrane, which mediated by acyl-coA synthetase long chain family member 4 (ACSL4) impaired the sensitivity of melanoma cells to platinum-based drugs.

[ACS Nano] Nanofibrous microspheres (NMs) demonstrated enhanced cell adhesion to human dermal fibroblasts during an in vitro cytocompatibility assessment. Additionally, NMs promoted host cell infiltration, neovascularization, and re-epithelialization in a diabetic mouse wound model.

[NPJ Regenerative Medicine] Genetic and pharmacological inhibitions of NOX2 in macrophages and bioengineered skin infected with Staphylococcus aureus and treated with cold atmospheric plasma reduced intracellular oxidants and increased bacterial survival.

[Nature Reviews Molecular Cell Biology] Investigators discuss the diverse roles integrins have during cancer progression from cell migration across varied ECM landscapes to breaching barriers such as the basement membrane, and eventual colonization of distant organs.

[Cell Death Discovery] Scientists review the intrinsic mechanisms of tissue repair and remodeling via ferroptosis in different organs and systems under various conditions, including the inflammatory response in skin wounds, remodeling of joints and cartilage, and fibrosis in multiple organs.

[Science Advances] Researchers interrogated the in vivo molecular structure changes of collagen in rat Achilles tendons following treadmill running.

[Circulation Research] Investigators proposed decreased low-density lipoprotein receptor-related protein 1 (LRP1) expression in smooth muscle cells to remodel the extracellular matrix enhanced by TGF-β as a potential mechanism of this pleiotropic locus for vascular diseases.

[Bioactive Materials] The authors examined how the physiochemical and biological properties of ECM hydrogels derived from human bone ECM could be controlled by manipulating bone powder size and ECM composition through modulation of enzyme digestion time.