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Novartis Receives Positive CHMP Opinion for Tabrecta® for Patients with METex14 Advanced Non-Small Cell Lung Cancer

[Novartis] Novartis announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency adopted a positive opinion and recommended granting marketing authorization of Tabrecta® as a monotherapy for the treatment of adults with advanced NSCLC.

Newsletters

ImmunityBio Announces First Participants Have Been Enrolled in Lung-MAP Trial Studying Anktiva to Activate NK and T Cells in Non-Small Cell Lung Cancer

[ImmunityBio, Inc.] ImmunityBio, Inc. announced that the first participants have been enrolled in a study that is part of an 800-site master protocol trial for NSCLC. The Lung Cancer Master Protocol trial (Lung-MAP) includes a study of Anktiva™ plus Keytruda versus investigator choice of standard-of-care chemotherapy in patients with NSCLC.

Newsletters

Incyte Announces Positive CHMP Opinion For Capmatinib (Tabrecta®) For The Treatment Of METex14 Advanced Non-Small Cell Lung Cancer

[Incyte, Inc.] Incyte, Inc. announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency’s has issued a positive opinion that recommends granting marketing authorization for capmatinib as a monotherapy for the treatment of adults with advanced NSCLC.

Muscle Cell News

MFG-E8 Promotes Osteogenic Transdifferentiation of Smooth Muscle Cells and Vascular Calcification by Regulating TGF-β1 Signaling

[Communications Biology] Scientists hypothesized that milk fat globule–epidermal growth factor 8 (MFG-E8), a glycoprotein expressed in vascular smooth muscle cells (VSMCs), promoted the osteogenic transdifferentiation of VSMCs through the activation of transforming growth factor-β1 (TGF-β1)-mediated signaling.

Muscle Cell News

Long Noncoding RNA ZFP36L2-AS Functions as a Metabolic Modulator to Regulate Muscle Development

[Cell Death & Disease] In vitro, ZFP36L2-AS inhibited myoblast proliferation but promoted myoblast differentiation.

Muscle Cell News

Oxidative Stress Generated by Polycyclic Aromatic Hydrocarbons from Ambient Particulate Matter Enhance Vascular Smooth Muscle Cell Migration through MMP Upregulation and Actin Reorganization

[Particle and Fibre Toxicology] The effects of polycyclic aromatic hydrocarbons, major components of particulate matter, on vascular smooth muscle cell migration and the underlying mechanisms were examined.

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circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

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