Ishira

Muscle Cell News

Fat Mass and Obesity-Associated Gene (FTO) Hypermethylation Induced by Decabromodiphenyl Ethane Causing Cardiac Dysfunction via Glucolipid Metabolism Disorder

[Ecotoxicology and Environmental Safety] Histopathological analysis demonstrated that decabromodiphenyl ethane (DBDPE) induced cardiomyocyte injury and fibrosis, and ultrastructural observation revealed that DBDPE could induce mitochondria damage and dissolution.

Muscle Cell News

The Effects of Xeno-Free Cryopreservation on the Contractile Properties of Human iPSC Derived Cardiomyocytes

[Journal of Molecular and Cellular Cardiology] The authors observed that cryopreservation altered the functionality and transcriptome of Human-induced pluripotent stem cell (iPSC)-derived cardiomyocytes towards larger sizes and contractile force as assessed by increased spread area and volume, single cell traction force microscopy and delayed calcium dynamics.

Muscle Cell News

Biological Effect of Dysregulated LBX1 on Adolescent Idiopathic Scoliosis through Modulating Muscle Carbohydrate Metabolism

[Spine Journal] Overexpressing LBX1 in human skeletal muscle myoblast cells led to increased expression of 3 differentially expressed proteins (DEPs) and decreased expression of three DEPs, respectively.

Muscle Cell News

Supraphysiological Activation of TAK1 Promotes Skeletal Muscle Growth and Mitigates Neurogenic Atrophy

[Nature Communications] The authors demonstrated that supraphysiological activation of TAK1 in skeletal muscle of adult mice stimulated translational machinery, protein synthesis, and myofiber growth.

Muscle Cell News

Single-Cell RNA Sequencing Reveals Heterogeneity of Myf5-Derived Cells and Altered Myogenic Fate in the Absence of SRSF2

[Advanced Science] Single-cell RNA-sequencing revealed high heterogeneity of myf5-derived cells and non-myogenic cells were significantly increased at the expense of skeletal muscle cells in the absence of SRSF2, reflecting altered cell fate.

Muscle Cell News

MiR-654-5p Suppresses Migration and Proliferation of Vascular Smooth Muscle Cells by Targeting ADAMTS-7

[Cells Tissues Organs] Investigators evaluated the role of miR-654-5p in vascular smooth muscle cells (VSMCs) involved in coronary artery disease. MiR-654-5p mimic or inhibitor was transfected into human VSMCs to assess its role on cell migration and proliferation.

1...606162 Page 61 of 62

circCDK13-Loaded Small Extracellular Vesicles Accelerate Healing in Preclinical Diabetic Wound Models

[Nature Communications] Scientists demonstrated that circCDK13 could stimulate the proliferation and migration of human dermal fibroblasts and human epidermal keratinocytes by interacting with insulin-like growth factor 2 mRNA binding protein 3 in an N6-Methyladenosine-dependent manner to enhance CD44 and c-MYC expression.

Wnt/β-Catenin Signaling, Epithelial-Mesenchymal Transition and Crosslink Signaling in Colorectal Cancer Cells

[Biomedicine & Pharmacotherapy] The authors summarize recent molecular studies on the role of the Wnt/β-catenin signaling axis in regulating epithelial-mesenchymal transition (EMT) in colorectal cancer cells, which triggers metastatic pathogenesis.

Innovent Receives NMPA Breakthrough Therapy Designation for IBI343 (Anti-Claudin18.2 ADC) as Monotherapy for Advanced Gastric Cancer

[Innovent Biologics, Inc.] Innovent Biologics, Inc. announced that the Center for Drug Evaluation of China’s National Medical Products Administration has granted Breakthrough Therapy Designation for IBI343 as monotherapy for the treatment of claudin18.2-positive advanced gastric/gastro-esophageal junction adenocarcinoma patients who have progressed after at least 2 lines of prior systematic treatments.

All Articles by Author:

Ishira

Popular