 | | Vol. 16.30 – 3 August, 2022 |
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| Scientists demonstrated that whole-brain colonization was fueled by glioblastoma cells that lacked connections with other tumor cells and astrocytes yet received synaptic input from neurons.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated a new tumor-suppressive function of epidermal growth factor receptor (EGFR) in EGFR-amplified glioblastomas regulated by EGFR ligands.
[Nature Cell Biology] |
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| Scientists showed that ORMDL binding to the holoenzyme complex was impaired in cells expressing pathogenic SPTLC1-ALS alleles, resulting in increased sphingolipid synthesis and a distinct lipid signature.
[Journal of Clinical Investigation] |
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| It was found that SDC1 and TGM2 proteins were overexpressed in radioresistant glioblastoma cells and tissues and they contributed to the poor prognosis of radiotherapy.
[Autophagy] |
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| Researchers developed in vitro assays to analyze the motility of heterodimeric motors composed of wild-type and mutant KIF1A.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists used patient-derived glioma stem cells and human glial cells to create a four-component 3D model of this environment informed by resected patient tumors.
[npj Precision Oncology] |
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| Using the freeze-drying technique, porous 3D composite scaffolds consisting of poly (3,4-ethylene-dioxythiophene) doped with polystyrene sulfonate, containing extracellular matrix (ECM) components were engineered for hosting neuronal cells.
[Advanced Healthcare Materials] |
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| The authors showed that female cells were more sensitive to radiation, and that senescence represented a major component of the radiation therapeutic response in both sexes.
[Communications Biology] |
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| Using an integrated approach that includes proteomics, transcriptomics and metabolic profiling, scientists identified praja2, a RING E3 ubiquitin ligase, as the key component of a signaling network that regulates glioblastoma cell growth and metabolism.
[Communications Biology] |
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| Researchers characterized CD95 and CD95L expression in human glioma-initiating cells, a glioblastoma cell population with stem cell features, and investigated the consequences of CRISPR-Cas9-mediated CD95 or CD95L gene deletion.
[Cell Death Discovery] |
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| Investigators discuss the functional roles of these genes in synaptogenesis and synaptic functions under physiological conditions, and how their functions are dysregulated in Alzheimer’s disease.
[Seminars in Cell & Developmental Biology] |
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| The Brain & Behavior Research Foundation announced the winners of its 2022 Klerman and Freedman Prizes, recognizing exceptional clinical and basic research in mental illness.
[Brain & Behavior Research Foundation] |
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| September 27 – 29, 2022
Leuven, Belgium |
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| | Karolinska Institutet – Solna, Sweden |
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| | Jülich Research Centre – Jülich, Germany |
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| | CRUK Manchester Institute – Manchester, United Kingdom |
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| | Sanford Research – Sioux Falls, South Dakota, United States |
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| | University of Lausanne – Lausanne, Switzerland |
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