Pulmonary Cell News Volume 11.25 | Jun 30 2022

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    2022-06-30 | PULCN 11.25


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.25 – 29 June, 2022
    TOP STORY

    Biomarkers of Airway Immune Homeostasis Differ Significantly with Generation of E-Cigarettes

    Scientists collected induced sputum samples from a cohort of non-smokers, smokers, 3rd generation e-cigarette users, and 4th generation e-cigarette users and evaluated the cellular and fluid phase composition for markers of inflammation, host defense, and lung injury.
    [American Journal of Respiratory and Critical Care Medicine]

    Abstract
    Facts above claims. Three scientists peer reviewed a life science vendor to get to the truth. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    α and β Catalytic Subunits of cAMP-Dependent Protein Kinase Regulate Formoterol-Induced Inflammatory Gene Expression Changes in Human Bronchial Epithelial Cells

    Researchers compared the genomic effects of formoterol, a β2-adrenoceptor agonist, with forskolin in human primary bronchial epithelial cells.
    [British Journal of Pharmacology]

    Abstract

    Characterization of a Flexible AAV-DTR/DT Mouse Model of Acute Epithelial Lung Injury

    Investigators developed a novel and flexible mouse model of acute epithelial lung injury based on adeno-associated virus (AAV) variant 6.2 mediated expression of the human diphtheria toxin receptor (DTR).
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    SM22α Cell Specific HIF Stabilization Mitigates Hyperoxia-Induced Neonatal Lung Injury

    Scientists determined whether hypoxia-inducible factors (HIF) stabilization in SM22α expressing cells mitigated hyperoxia-induced neonatal lung injury.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Increased Susceptibility of Irradiated Mice to Aspergillus fumigatus Infection via NLRP3/GSDMD Pathway in Pulmonary Bronchial Epithelia

    The authors established a mouse model to explore the effect of radiation on Aspergillus fumigatus infection and the associated mechanisms.
    [Cell Communication and Signaling]

    Full Article

    Expression of DEL-1 in Alveolar Epithelial Cells Prevents Lipopolysaccharide-Induced Inflammation, Oxidative Stress, and Eosinophil Recruitment in Acute Lung Injury

    Researchers investigated the role of developmental endothelial locus-1 (DEL-1) in lipopolysaccharide-induced acute lung injury in mouse models and its ability to regulate on eosinophil recruitment.
    [International Immunopharmacology]

    Abstract

    Biodegradable and Inherently Fluorescent pH-Responsive Nanoparticles for Cancer Drug Delivery

    Scientists developed two novel pH-only and pH- and thermo-responsive theranostic nanoparticle formulations to deliver an anticancer drug and track the accumulation and therapeutic efficacy of the formulations through inherent fluorescence.
    [Pharmaceutical Research]

    Abstract

    Designed miR-19a/B Sponge Induces Apoptosis in Lung Cancer Cells Through the PI3K-PTEN-Akt Pathway Regulation

    Investigators designed an miR-19a/b sponge plasmid and transfected it into A549 lung cancer cell lines and analyzed its effects on PTEN and TP53INP1 gene expression as the main miR-19a/b target and apoptosis rate in these cell lines.
    [Molecular Biology Reports]

    Abstract

    miR-181a-5p Restrains Non-Small Cell Lung Cancer Cell Invasion and Migration by Regulating the GTSE1/p53/NF-κB Axis

    Researchers investigated the role of miR-181a-5p in lung cancer. Expression patterns of miR-181a-5p and G2 and S phase-expressed-1 in the human NSCLC cell line A549 and normal lung epithelial cell line BASE-2B were detected.
    [Cells Tissues Organs]

    Abstract

    PneumaCult for primary airway epithelial cell culture at the air-liquid interface or as airway organoid.
    REVIEWS

    Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2021

    The authors reviewed and discussed the status of active research areas involving stem cells, cellular therapeutics, and bioengineering as they relate to the human lung.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    AN2 Therapeutics Initiates Pivotal Phase II/III Trial Evaluating Epetraborole for Treatment-Refractory MAC Lung Disease

    AN2 Therapeutics, Inc. announced it has screened its first patient in its pivotal Phase II/III clinical trial evaluating once-daily, oral epetraborole for treatment-refractory Mycobacterium avium complex (MAC) lung disease, the most common form of nontuberculous mycobacterial lung disease.
    [AN2 Therapeutics, Inc.]

    Press Release

    Perlmutter Cancer Center Is Among Four New York City Cancer Centers to Receive $1 Million Grant to Improve Lung Cancer Care for Underserved Minorities

    A team of New York City lung cancer experts, led by investigators at NYU Langone Health’s Perlmutter Cancer Center, have received a three-year, $1 million grant from Stand Up To Cancer® to bring technology-enabled immunotherapy monitoring to under-represented patient populations.
    [NYU Langone Health]

    Press Release
    FEATURED EVENT

    12th AACR-JCA Conference: Breakthroughs in Cancer Research

    December 10 – 14, 2022
    Maui, Hawai’i, United States
    JOB OPPORTUNITIES

    Postdoctoral Fellow Positions – Translational Research

    University of Maryland School of Medicine – Baltimore, Maryland, United States

    Associate Professor – Division of Thoracic Surgery

    McGill University – Montreal, Quebec, Canada

    Research Technologist – Pediatrics

    Pennsylvania State University – State College, Pennsylvania, United States

    Postdoctoral Fellow – Cancer Biology and Cancer Immunology

    Icahn School of Medicine at Mount Sinai – New York, New York, United States

    Postdoctoral Fellow – Interorgan Crosstalk

    Washington University School of Medicine – St. Louis, Missouri, United States

    > See All Jobs

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