IFN-λ Drives Distinct Lung Immune Landscape Changes and Antiviral Responses in Human Metapneumovirus Infection

Scientists showed that type III interferon (IFN-λ) was highly upregulated during human metapneumovirus infection in vitro in human and mouse airway epithelial cells and in vivo in mice. They found through several immunological and molecular assays that type II alveolar cells are the primary producers of IFN-λ.