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Pulmonary Cell NewsResearchers showed that Dynole 34-2, a potent inhibitor of Dynamin GTPase activity, could block transduction of key signaling pathways and overcome chemoresistance of leukemia stem cells.
[Nature Communications]
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Tremblay, C. S., Chiu, S. K., Saw, J., McCalmont, H., Litalien, V., Boyle, J., Sonderegger, S. E., Chau, N., Evans, K., Cerruti, L., Salmon, J. M., McCluskey, A., Lock, R. B., Robinson, P. J., Jane, S. M., & Curtis, D. J. (2020). Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells. Nature Communications, 11(1), 6211. https://doi.org/10.1038/s41467-020-20091-6 Cite
