Effects of the DRD2/3 Antagonist ONC201 and Radiation in Glioblastoma

Investigators suggested that combined treatment with the DRD2/3 antagonist ONC201 and radiation improves the efficacy of radiation against glioblastoma (GBM) in vitro and in vivo through suppression of glioma-initiating cells without increasing toxicity in mouse models of GBM.