Preferential Interaction of Platelets with Prostate Cancer Cells with Stem Cell Markers

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Scientists characterized the mechanisms behind prostate CSC-platelet interaction. Fluorescence Activated Cell Sorting was utilized to separate DU145 and PC3 prostate cancer cells into CD133+/CD44+, CD133+/CD44, CD44+/CD133, and CD133/CD44 subpopulations and to measure their CXCR4 surface expression.
[Thrombosis Research]
Rudzinski, J. K., Govindasamy, N. P., Asgari, A., Saito, M. S., Lewis, J. D., & Jurasz, P. (2021). Preferential interaction of platelets with prostate cancer cells with stem cell markers. Thrombosis Research, 206, 42–51. https://doi.org/10.1016/j.thromres.2021.08.008 Cite
Abstract