Sulfarotene, a Synthetic Retinoid, Overcomes Stemness and Sorafenib Resistance of Hepatocellular Carcinoma via Suppressing SOS2-RAS Pathway

Researchers evaluated the pharmacology and mechanism of sulfarotene, a new type of synthetic retinoid, on the cancer stem cell-like properties of hepatocellular carcinoma (HCC) tumor-repopulating cells, and assessed its preclinical efficacy in models of HCC patient-derived xenografts