Scientists demonstrated that grafts based on porous collagen-based scaffolds, similar to biomaterials utilized clinically in induced regeneration, could deliver and protect embryonic neural stem cells at spinal cord injury (SCI) sites, leading to significant improvement in locomotion recovery in an experimental mouse SCI model.
[NPJ Regenerative Medicine]
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Kourgiantaki, A., Tzeranis, D. S., Karali, K., Georgelou, K., Bampoula, E., Psilodimitrakopoulos, S., Yannas, I. V., Stratakis, E., Sidiropoulou, K., Charalampopoulos, I., & Gravanis, A. (2020). Neural stem cell delivery via porous collagen scaffolds promotes neuronal differentiation and locomotion recovery in spinal cord injury. Npj Regenerative Medicine, 5(1), 1–14. https://doi.org/10.1038/s41536-020-0097-0 Cite