Protease Nexin-1 Deficiency Increases Mouse Hindlimb Neovascularisation Following Ischemia and Accelerates Femoral Artery Perfusion

In wild-type (WT) muscle, investigators observed an upregulation of PN-1 mRNA and protein after ischemia. Angiography analysis showed that femoral artery perfusion was more rapidly restored in PN-1−/− mice than in WT mice.