Using a syngeneic hepatoceullar carcinoma (HCC) mouse model, the authors demonstrated that treatment with apatinib resulted in attenuation of tumor growth and increased tumor vessel normalization. Results indicated that NK cells, but not CD4+ or CD8+ T cells mediated the therapeutic efficacy of apatinib in HCC mouse models.
[Cancer Gene Therapy]
6445212 W9UB85HL items 1 apa 0 default asc 1 150909 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-e59c8ee56cfa060db16398dd30156f70%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22W9UB85HL%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%202em%3B%20text-indent%3A-2em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EApatinib%20prevents%20natural%20killer%20cell%20dysfunction%20to%20enhance%20the%20efficacy%20of%20anti-PD-1%20immunotherapy%20in%20hepatocellular%20carcinoma%20%7C%20Cancer%20Gene%20Therapy.%20%28n.d.%29.%20Retrieved%20June%2019%2C%202020%2C%20from%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41417-020-0186-7%27%3Ehttps%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41417-020-0186-7%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DW9UB85HL%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22webpage%22%2C%22title%22%3A%22Apatinib%20prevents%20natural%20killer%20cell%20dysfunction%20to%20enhance%20the%20efficacy%20of%20anti-PD-1%20immunotherapy%20in%20hepatocellular%20carcinoma%20%7C%20Cancer%20Gene%20Therapy%22%2C%22creators%22%3A%5B%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41417-020-0186-7%22%2C%22language%22%3A%22%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222020-06-19T17%3A17%3A20Z%22%7D%7D%5D%7DApatinib prevents natural killer cell dysfunction to enhance the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma | Cancer Gene Therapy. (n.d.). Retrieved June 19, 2020, from
https://www.nature.com/articles/s41417-020-0186-7 Cite