Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe authors focus on the latest research and applications of human-derived umbilical cord MSC in the treatment and management of T2DM, exploring and systematizing the key effects of both umbilical cord MSC and its factor-rich secretome accordingly with the major complications associated to T2DM.
[Cell and Tissue Research]
6445218 5BB43UC9 items 1 apa 0 default asc 1 163087 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-2bbbdd3ba5e3cc9f2804da3c17197aea%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%225BB43UC9%22%2C%22library%22%3A%7B%22id%22%3A6445218%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gomes%20et%20al.%22%2C%22parsedDate%22%3A%222021-05-29%22%2C%22numChildren%22%3A0%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGomes%2C%20A.%2C%20Coelho%2C%20P.%2C%20Soares%2C%20R.%2C%20%26amp%3B%20Costa%2C%20R.%20%282021%29.%20Human%20umbilical%20cord%20mesenchymal%20stem%20cells%20in%20type%202%20diabetes%20mellitus%3A%20the%20emerging%20therapeutic%20approach.%20%3Ci%3ECell%20and%20Tissue%20Research%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00441-021-03461-4%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00441-021-03461-4%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445218%26amp%3Bitem_key%3D5BB43UC9%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Human%20umbilical%20cord%20mesenchymal%20stem%20cells%20in%20type%202%20diabetes%20mellitus%3A%20the%20emerging%20therapeutic%20approach%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Andreia%22%2C%22lastName%22%3A%22Gomes%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Pedro%22%2C%22lastName%22%3A%22Coelho%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Soares%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Raquel%22%2C%22lastName%22%3A%22Costa%22%7D%5D%2C%22abstractNote%22%3A%22The%20umbilical%20cord%20has%20been%20proved%20to%20be%20an%20easy-access%2C%20reliable%2C%20and%20useful%20source%20of%20mesenchymal%20stem%20cells%20%28MSC%29%20for%20clinical%20applications%20due%20to%20its%20primitive%2C%20immunomodulatory%2C%20non-immunogenic%2C%20secretory%20and%20paracrine%2C%20migratory%2C%20proliferative%2C%20and%20multipotent%20properties.%20This%20set%20of%20characteristics%20has%20recently%20attracted%20great%20research%20interest%20in%20the%20fields%20of%20nanotechnology%20and%20regenerative%20medicine%20and%20cellular%20therapy.%20Accumulating%20evidence%20supports%20a%20pronounced%20therapeutic%20potential%20of%20MSC%20in%20many%20different%20pathologies%2C%20from%20hematology%20to%20immunology%2C%20wound-healing%2C%20tissue%20regeneration%2C%20and%20oncology.%20Diabetes%20mellitus%2C%20branded%20the%20epidemic%20of%20the%20century%2C%20is%20considered%20a%20chronic%20metabolic%20disorder%2C%20representing%20a%20major%20burden%20for%20health%20system%20sustainability%20and%20an%20important%20public%20health%20challenge%20to%20modern%20societies.%20The%20available%20treatments%20for%20type%202%20diabetes%20mellitus%20%28T2DM%29%20still%20rely%20mainly%20on%20combinations%20of%20oral%20antidiabetic%20agents%20with%20lifestyle%20and%20nutritional%20adjustments.%20Despite%20the%20continuous%20development%20of%20novel%20and%20better%20hypoglycemic%20drugs%2C%20their%20efficacy%20is%20limited%20in%20the%20installment%20and%20progression%20of%20silent%20T2DM%20complications.%20T2DM%20comorbidities%20and%20mortality%20rates%20still%20make%20it%20a%20serious%2C%20common%2C%20costly%2C%20and%20long-term%20manageable%20disease.%20Recently%2C%20experimental%20models%2C%20preclinical%20observations%2C%20and%20clinical%20studies%20have%20provided%20some%20insights%20and%20preliminary%20promising%20results%20using%20umbilical%20cord%20MSCs%20to%20treat%20and%20manage%20diabetes.%20This%20review%20focuses%20on%20the%20latest%20research%20and%20applications%20of%20human-derived%20umbilical%20cord%20MSC%20in%20the%20treatment%20and%20management%20of%20T2DM%2C%20exploring%20and%20systematizing%20the%20key%20effects%20of%20both%20umbilical%20cord%20MSC%20and%20its%20factor-rich%20secretome%20accordingly%20with%20the%20major%20complications%20associated%20to%20T2DM.%22%2C%22date%22%3A%222021-05-29%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1007%5C%2Fs00441-021-03461-4%22%2C%22ISSN%22%3A%221432-0878%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1007%5C%2Fs00441-021-03461-4%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-06-03T23%3A12%3A40Z%22%7D%7D%5D%7D
Gomes, A., Coelho, P., Soares, R., & Costa, R. (2021). Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach. Cell and Tissue Research. https://doi.org/10.1007/s00441-021-03461-4 Cite
