B Cell Depletion Abrogates Immune Mediated Cytopenia and Rejection of Cord Blood Transplantation in Hurler Syndrome

Researchers studied 57 patients in two centers who received myeloablative conditioning for cord blood transplant in Hurler syndrome, and reported a significant improvement in event-free survival with reduced incidence of graft failure and without any evidence of immune-mediated cytopenia in those patients that had received rituximab.