[PLOS One] Investigators achieved the successful differentiation of nail stem-like cells from human-iPSCs via digit organoids by stepwise stimulation, tracing the molecular processes involved in limb development.

[Microsystems & Nanoengineering] Scientists presented a flexible silk fibroin-based triboelectric nanogenerator that featured an on-skin substrate and is characterized by excellent skin compliance and air/water permeability.

[Washington University] Washington University is thrilled to announce that Dr. Shiming Chen has been awarded a Seed grant from the Center of Regenerative Medicine for her groundbreaking project titled “hiPSC-induced retinal organoids modeling CRX-linked retinopathies.”

[Nature] Investigators performed single-nucleus RNA sequencing on 47 liver biopsies from patients with different stages of metabolic dysfunction-associated steatotic liver disease to establish a cellular map of the liver during disease progression.

[Gut] Researchers found that alcohol binges in MASH increased liver injury and fibrosis. Liver transcriptomic profiling revealed differential expression of genes involved in extracellular matrix reorganisation, neutrophil activation and inflammation compared with alcohol or the MASH diet alone.

[Journal of Hepatology] Scientists summarize the crosstalk between liver sinusoidal endothelial cells, HSCs, hepatocytes, cholangiocytes, and immune cells in health and disease and comment on potential novel therapeutic methods for treating liver diseases.

[Texas Public Radio] University of Texas (UT) School of Public Health San Antonio received nearly $3 million in new funding on May 20th. Almost $2 million will go into research for hepatic steatosis, commonly known as fatty liver disease.

[Aging] Various databases were applied to observe the CUL2 expression. Kaplan-Meier and Spearman correlation analyses were employed to investigate the potential links between CUL2 level, patient prognosis, and the infiltration of immune cells.

[Cell Death Discovery] Using three laminopathy models, researchers found that increased p53 activity in Lmna-mutant muscle cells primarily resulted from mechanically induced damage to the myonuclei, and not from altered transcriptional regulation due to loss of lamin A/C expression.

[Scientific Reports] Investigators studied the inhibitory actions of docosahexaenoic acid on the contractions induced by carbachol, angiotensin II, and bradykinin in guinea pig gastric fundus smooth muscle, particularly focusing on the possible inhibition of store-operated Ca2+ channels .

[Blood] The authors propose that the targeted modulation of the tumor microenvironment provides new therapeutic options for this group of "double refractory" patients.

[Biomaterials] The authors performed transcriptome and proteome sequencing on human adipose-derived MSCs cultured on the “all-in-one” gel microsphere culture system and the Petri dish culture system.