AKT

[Scientific Reports] Scientists demonstrated that the expression of peptidylarginine deiminase 2 (PAD2), an enzyme that catalyzes protein citrullination, was increased in lung homogenates from subjects with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and their lung fibroblasts.

[Plant Foods For Human Nutrition] Investigators studied the metabolic effect of resveratrol around the circadian clock in order to determine more accurately the hepatic signaling pathways involved. AML-12 hepatocytes were treated with resveratrol and clock and metabolic markers were measured around the clock.

[Translational Oncology] The authors summarize the original data obtained from international research laboratories on the oncogenic alterations in each component of the PI3K/Akt/mTOR pathway in lung cancer.

[Oncogenesis] The authors provided the first evidence for the existence of GalNAc-type O-glycans on TrkA and altered O-glycan structures by core 1 β1,3-galactosyltransferase (C1GALT1) could regulate TrkA signaling in neuroblastoma cells.

[Cell Reports] The authors identified renal Klotho and inorganic phosphate as extrinsic factors that antagonistically regulate HSC maintenance in the bone marrow.

[Nature Communications] Scientists showed that IL-18 was a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier.