AKT

[Cancer Discovery] Lentiviral barcoding/single cell RNA-sequencing reveal that HER2+ breast cancer cells cycle stochastically through a "pre-drug-tolerant persister" state, characterized by a G0-like expression signature and enriched for diapause and/or senescence genes.

[Frontiers in Cell and Developmental Biology] Scientists found that halofuginone inhibited the proliferation, induced G0/G1 phase arrest, and promoted apoptosis in lung cancer cells in a dose-dependent manner.

[Toxicology] Scientists explored the toxic effects and mechanisms of trichloroethylene (TCE) on hESC proliferation. TCE exposure resulted in upregulation of Cx43 via Akt phosphorylation, consequently stimulated CDK2 expression, contributing to hyper-proliferation in hESCs.

[Translational Oncology] Investigators found that overexpression of Rec8 meiotic recombination protein (Rec8) facilitated the migration and invasion of colorectal cancer cells (CRC) in vitro and promoted the liver metastasis of CRC in vivo.

[British Journal of Pharmacology] Investigators explored the role of BTK on the migration of myeloid cells; in vitro using chemotaxis assays and in vivo using zymosan induced peritonitis as model systems.

[Proceedings of the National Academy of Sciences of the United States of America] Using human cultured endothelial cells, scientists found that endogenous protease-activated receptor-1 (PAR1) and sphingosine-1-phosphate receptor-1 (S1PR1) coexisted in caveolin-1–rich microdomains and that S1PR1 co-association with Cav1 was increased by activated protein C (aPC) activation of PAR1.