AKT

[Cell Death & Disease] Scientists evaluated the functional role of BRD9 in gastrointestinal stromal tumors (GIST) progression. Their findings demonstrated that the expression of BRD9 was upregulated in GIST tissues.

[Scientific Reports] Scientists evaluated the delay and protection of Aronia melanocarpa polysaccharide (AMP) obtained from Aronia melanocarpa fruit on aging mice by D-Galactose induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice.

[Molecular Biology Reports] The authors elucidated the modulation patterns between apoptosis and autophagy following dual inhibition by Akt inhibitor erufosine and Bcl-2 inhibitor ABT-737 in castration-resistant prostate cancer cell lines, PC-3 (Bax+) and DU-145 (Bax−).

[Communications Biology] Researchers showed a new method for automated engineering of 3D human skeletal muscle models in microplates and functional compound screening to address the lack of muscle wasting disease medication.

[Aging] Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing lung adenocarcinoma proliferation, invasion, and migration by inhibiting miR-188-5p.

[Journal of Molecular Histology] The authors investigated whether stromal cell-derived factor (SDF)-1 secreted by mesenchymal stem cells contributed to endothelial progenitor cell migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases/protein kinase B signaling pathway.