AKT

[Scientific Reports] Scientists analyzed sex-specific fetal distal lung epithelial cells exposed to epidermal growth factor and related ligands with Ussing chambers, RT-qPCR and Western blots.

[Scientific Reports] Human umbilical vascular endothelial cells were cultured with or without COL-4A1 and TNF-α. Cell Counting Kit-8, wound-healing, Transwell and tube formation assays were used to evaluate cell proliferation, migration and angiopoiesis.

[Oncogene] Researchers reported that the expression of CRYβB2 in breast cancer cells increased stemness, growth, and metastasis. Transcriptomics data revealed that CRYβB2 upregulated genes that were functionally associated with unfolded protein response, oxidative phosphorylation, and DNA repair, while down-regulating genes related to apoptosis.

[Oncogene] Investigators generated gene knockouts through genome editing, performed RNA interference-mediated knockdown of gene expression, and ectopically expressed CHRNB2 in gastric cancer cells.

[Cell Reports] Researchers identified pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 as phosphatases whose upregulation led to β-cell failure in diabetes.

[Nature Communications] Scientists showed that exon 2 inclusion in the U2AF2 mRNA is a cell cycle-dependent process that is regulated by LEDGF/SRSF1 splicing complexes, whose assembly was controlled by the IWS1 phosphorylation-dependent deposition of histone H3K36me3 marks in the body of target genes.