AKT3-Mediated IWS1 Phosphorylation Promotes the Proliferation of EGFR-Mutant Lung Adenocarcinomas through Cell Cycle-Regulated U2AF2 RNA Splicing

Scientists showed that exon 2 inclusion in the U2AF2 mRNA is a cell cycle-dependent process that is regulated by LEDGF/SRSF1 splicing complexes, whose assembly was controlled by the IWS1 phosphorylation-dependent deposition of histone H3K36me3 marks in the body of target genes.