ATP-binding cassette

[Carcinogenesis] Inhibition of Laminin γ2 (LAMC2) in pancreatic cancer (PC) cells enhanced the gemcitabine sensitivity and induction of apoptosis. It inhibited colony formation ability, migration, and invasion potential.

[Archives of Biochemistry and Biophysics] The biological roles of Pentraxin 3 in NSCLC progression and NSCLC cell resistance to cisplatin were evaluated using enzyme-linked immunosorbent assay, cell count kit-8, colony formation assay, flow cytometry, as well as xenograft tumor assay.

[Cell Reports Medicine] A leaky vasculature resulted in higher docetaxel tumor levels compared to normal brain. Nevertheless, Abcb1 could reduce drug distribution and efficacy even in leaky models.

[Current Stem Cell Research & Therapy] Stem cells from human exfoliated deciduous teeth-derived hepatocytes were intrasplenically transplanted into chronically CCl4-treated liver fibrosis model mice, followed by the analysis of donor integration and hepatobiliary metabolism in vivo.

[Scientific Reports] Human airway epithelial cells were used to test the efficacy of cyclic AMP modulation by ABCC4 and PDE-4 inhibition through a series of concentration–response studies.

[Cell Death Discovery] Scientists found that the CCAAT/Enhancer-binding protein delta (CEBPD) protein levels in glioblastoma patients were significantly increased and further contributed to temozolamide resistance by promoting glioma-like stem cell formation.