Inhibition of Laminin γ2 (LAMC2) in pancreatic cancer (PC) cells enhanced the gemcitabine sensitivity and induction of apoptosis. It inhibited colony formation ability, migration, and invasion potential.
[Carcinogenesis]
6606345 {6606345:9ZASSL7V} apa 50 1 159598 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-19f2f498308a759065f96461441059b2%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%229ZASSL7V%22%2C%22library%22%3A%7B%22id%22%3A6606345%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Okada%20et%20al.%22%2C%22parsedDate%22%3A%222021-02-24%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EOkada%2C%20Y.%2C%20Takahashi%2C%20N.%2C%20Takayama%2C%20T.%2C%20%26amp%3B%20Goel%2C%20A.%20%282021%29.%20LAMC2%20promotes%20cancer%20progression%20and%20gemcitabine%20resistance%20through%20modulation%20of%20EMT%20and%20ATP-binding%20cassette%20transporters%20in%20pancreatic%20ductal%20adenocarcinoma.%20%3Ci%3ECarcinogenesis%3C%5C%2Fi%3E%2C%20%3Ci%3Ebgab011%3C%5C%2Fi%3E.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcarcin%5C%2Fbgab011%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcarcin%5C%2Fbgab011%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6606345%26amp%3Bitem_key%3D9ZASSL7V%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22LAMC2%20promotes%20cancer%20progression%20and%20gemcitabine%20resistance%20through%20modulation%20of%20EMT%20and%20ATP-binding%20cassette%20transporters%20in%20pancreatic%20ductal%20adenocarcinoma%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yasuyuki%22%2C%22lastName%22%3A%22Okada%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Naoki%22%2C%22lastName%22%3A%22Takahashi%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Tetsuji%22%2C%22lastName%22%3A%22Takayama%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ajay%22%2C%22lastName%22%3A%22Goel%22%7D%5D%2C%22abstractNote%22%3A%22Pancreatic%20ductal%20adenocarcinoma%20%28PDAC%29%20is%20an%20aggressive%20disease%20with%20poor%20prognosis.%20Gemcitabine%20remains%20an%20effective%20option%20for%20the%20majority%20of%20PDAC%20patients.%20Unfortunately%2C%20currently%20no%20reliable%20prognostic%20and%20predictive%20biomarkers%20of%20therapeutic%20response%20are%20available%20for%20the%20patients%20with%20PDAC.%20Laminin%20%5Cu03b32%20%28LAMC2%29%20is%20overexpressed%20in%20several%20cancers%2C%20and%20its%20high%20expression%20facilitates%20cancer%20development%20and%20chemoresistance.%20However%2C%20its%20functional%20role%20in%20PDAC%20remains%20unclear%2C%20and%20a%20better%20understanding%20of%20this%20will%20likely%20help%20improve%20the%20prognosis%20of%20PDAC%20patients.%20This%20study%20aimed%20to%20elucidate%20the%20clinical%20and%20biological%20role%20of%20LAMC2%20in%20PDAC.%20We%20first%20analyzed%20the%20expression%20levels%20of%20LAMC2%20by%20real-time%20reverse%20transcription%20PCR%20in%20a%20cohort%20of%20114%20PDAC%20patients.%20Interestingly%2C%20higher%20expression%20of%20LAMC2%20significantly%20correlated%20with%20poor%20survival%20in%20PDAC%20cohort.%20In%20addition%2C%20elevated%20LAMC2%20expression%20served%20as%20a%20potential%20prognostic%20marker%20for%20survival.%20Subsequently%2C%20functional%20characterization%20for%20the%20role%20of%20LAMC2%20in%20PDAC%20was%20performed%20by%20small%20interfering%20RNA%20%28siRNA%29%20knockdown%20in%20pancreatic%20cancer%20%28PC%29%20cell%20lines.%20Interestingly%2C%20inhibition%20of%20LAMC2%20in%20PC%20cells%20enhanced%20the%20gemcitabine%20sensitivity%20and%20induction%20of%20apoptosis.%20Moreover%2C%20it%20inhibited%20colony%20formation%20ability%2C%20migration%2C%20and%20invasion%20potential.%20Furthermore%2C%20LAMC2%20regulated%20the%20expression%20of%20epithelial-mesenchymal%20transition%20%28EMT%29%20phenotype.%20In%20addition%2C%20LAMC2%20significantly%20correlated%20with%20genes%20associated%20with%20the%20expression%20of%20ATP-binding%20cassette%20%28ABC%29%20transporters%20in%20PC%20cells%20and%20PDAC%20patients.%20In%20conclusion%2C%20these%20results%20suggest%20that%20LAMC2%20regulates%20gemcitabine%20sensitivity%20through%20EMT%20and%20ABC%20transporters%20in%20PDAC%20and%20may%20be%20a%20novel%20therapeutic%20target%20in%20PDAC%20patients.%22%2C%22date%22%3A%22February%2024%2C%202021%22%2C%22language%22%3A%22%22%2C%22DOI%22%3A%2210.1093%5C%2Fcarcin%5C%2Fbgab011%22%2C%22ISSN%22%3A%220143-3334%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1093%5C%2Fcarcin%5C%2Fbgab011%22%2C%22deleted%22%3A1%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-02T20%3A03%3A51Z%22%7D%7D%5D%7D
Okada, Y., Takahashi, N., Takayama, T., & Goel, A. (2021). LAMC2 promotes cancer progression and gemcitabine resistance through modulation of EMT and ATP-binding cassette transporters in pancreatic ductal adenocarcinoma. Carcinogenesis, bgab011. https://doi.org/10.1093/carcin/bgab011 Cite