B cells

[PLoS Pathogens] Investigators examined the effect of transient breakdown of the immunological tolerance induced by Treg-cell depletion on adaptive immune responses against administered SARS-CoV-2 antigen, spike protein 1.

[International Journal For Parasitology] Scientists describe clonal expansion in the variable region of immunoglobulin heavy chains of antigen-specific single B cells collected from humans immunized with Pfs230D1-EPA or Pfs25-EPA conjugate vaccines formulated in Alhydrogel®.

[Journal of Cellular and Molecular Medicine] Researchers developed a 6-gene immune-related risk model to predict the survival of patients with lung adenocarcinoma (LUAD) in The Cancer Genome Atlas cohort based on TP53 status, and the predictive ability was confirmed in two independent cohorts.

[PLoS Pathogens] The authors reported that unlike susceptible C57BL/6J mice, A/J mice were highly resistant to secondary infection.

[Vincerx Pharma, Inc.] Vincerx Pharma, Inc. announced that the European Commission has granted Orphan Drug Designation to VIP152, the Company’s PTEFb/CDK9 inhibitor, for the treatment of diffuse large B cell lymphoma.

[Nature Cell Biology] The authors findings implicated retrotransposable element silencing in hematopoiesis and suggested a cross-talk between the H3.3 loading machinery and the pioneer transcription factor Pu.1.