B cells

[CRISPR Therapeutics] CRISPR Therapeutics announced that the FDA granted Regenerative Medicine Advanced Therapy designation to CTX110™, its wholly-owned allogeneic CAR-T cell therapy targeting CD19+ B-cell malignancies.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators revealed that IκB kinase (IKK)-α in distinct endothelial cell (EC)-derived compartments was uniquely required to promote B cell homeostasis and lymph node (LN) development, and they established that lymphatic EC-intrinsic IKK-α was absolutely essential for LN formation.

[Nature Reviews Disease Primers] VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.

[Cancer Research] Emerging evidence indicates B cell activating factor (BAFF) to be an important cytokine for anti-tumor immunity. The authors generated a BAFF-overexpressing B16.F10 melanoma cell model and found that BAFF-expressing tumors grew more slowly in vivo than control tumors.

[Journal of Experimental Medicine] Using single-cell RNA and ATAC sequencing, investigators showed that virus-responding CD4+ T cells lacking both Bcl6 and Blimp1 could differentiate into cells with transcriptomic, chromatin accessibility, and functional attributes of memory cells but not of follicular helper T cells.

[Journal of Translational Medicine] Scientists explored the function of circular RNA nucleolar and coiled-body phosphoprotein 1 (circNOLC1) in cancer stem cells of breast cancer and the inhibitory impact of propofol on circNOLC1.