Dependence on Bcl6 and Blimp1 Drive Distinct Differentiation of Murine Memory and Follicular Helper CD4⁺ T Cells

Using single-cell RNA and ATAC sequencing, investigators showed that virus-responding CD4+ T cells lacking both Bcl6 and Blimp1 could differentiate into cells with transcriptomic, chromatin accessibility, and functional attributes of memory cells but not of follicular helper T cells.