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B cells

CD200 Expression in Hematopoietic Neoplasms: Beyond a Marker for Diagnosis of B Cell Neoplasms

[Critical Reviews in Oncology Hematology] Investigators review CD200 expression and its role in the immune evasion of non-B cell hematopoietic neoplasms and conclude that CD200 appears to be involved in the immune evasion of malignant cells, which could affect the survival of patients.

Immune Memory from SARS-CoV-2 Infection in Hamsters Provides Variant-Independent Protection but Still Allows Virus Transmission

[Science Immunology] Scientists demonstrated that engagement of the innate immune system following SARS-CoV-2 infection was delayed but was followed by a pronounced adaptive response.

Cytoplasmic CD79a Is a Promising Biomarker for B Lymphoblastic Leukemia Follow Up Post CD19 CAR-T Therapy

[Leukemia & Lymphoma] Researchers investigated the efficiency and prognostic role of cytoplasmic CD79a antibody-gated multicolor flow cytometry in minimal residual disease detection in patients with B-ALL who received CD19-targeted chimeric antigen receptor (CAR) T-cell therapy bridging to allogeneic hematopoietic stem cell transplantation.

Impact of Intracellular Innate Immune Receptors on Immunometabolism

[Cellular & Molecular Immunology] Toll-like receptors, cytokine receptors, and T and B cell receptors have been shown to activate multiple downstream metabolic pathways. However, how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well understood.

B Cell to T Cell Ratio as a Novel Indicator in Flow Cytometry in the Diagnosis of Thyroid Lymphoma

[Endocrine Journal] Investigators retrospectively analyzed 26 patients with primary thyroid lymphomas and 16 patients with benign lymphoproliferative lesions.

Development of ICT01, a First-in-Class, Anti-BTN3A Antibody for Activating Vγ9Vδ2 T Cell–Mediated Antitumor Immune Response

[Science Translational Medicine] The authors described the development of a humanized monoclonal antibody, ICT01, with subnanomolar affinity for the three isoforms of BTN3A.

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