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B cells
Hematopoiesis News
CD200 Expression in Hematopoietic Neoplasms: Beyond a Marker for Diagnosis of B Cell Neoplasms
[Critical Reviews in Oncology Hematology] Investigators review CD200 expression and its role in the immune evasion of non-B cell hematopoietic neoplasms and conclude that CD200 appears to be involved in the immune evasion of malignant cells, which could affect the survival of patients.
Immunology of Infectious Disease News
Immune Memory from SARS-CoV-2 Infection in Hamsters Provides Variant-Independent Protection but Still Allows Virus Transmission
[Science Immunology] Scientists demonstrated that engagement of the innate immune system following SARS-CoV-2 infection was delayed but was followed by a pronounced adaptive response.
Cell Therapy News
Cytoplasmic CD79a Is a Promising Biomarker for B Lymphoblastic Leukemia Follow Up Post CD19 CAR-T Therapy
[Leukemia & Lymphoma] Researchers investigated the efficiency and prognostic role of cytoplasmic CD79a antibody-gated multicolor flow cytometry in minimal residual disease detection in patients with B-ALL who received CD19-targeted chimeric antigen receptor (CAR) T-cell therapy bridging to allogeneic hematopoietic stem cell transplantation.
Human Immunology News
Impact of Intracellular Innate Immune Receptors on Immunometabolism
[Cellular & Molecular Immunology] Toll-like receptors, cytokine receptors, and T and B cell receptors have been shown to activate multiple downstream metabolic pathways. However, how intracellular innate immune sensors/receptors intersect with metabolic pathways is less well understood.
Human Immunology News
B Cell to T Cell Ratio as a Novel Indicator in Flow Cytometry in the Diagnosis of Thyroid Lymphoma
[Endocrine Journal] Investigators retrospectively analyzed 26 patients with primary thyroid lymphomas and 16 patients with benign lymphoproliferative lesions.
Immune Regulation News
Development of ICT01, a First-in-Class, Anti-BTN3A Antibody for Activating Vγ9Vδ2 T Cell–Mediated Antitumor Immune Response
[Science Translational Medicine] The authors described the development of a humanized monoclonal antibody, ICT01, with subnanomolar affinity for the three isoforms of BTN3A.