B cells

[Cell Reports] Researchers demonstrated that less complex B cell evolutionary pathways than those naturally observed existed for the induction of HIV bnAbs by vaccination, and they established rational approaches to identify boosting candidate immunogens.

[Immunity] Scientists analyzed receptor binding domain-binding monoclonal antibodies derived from SARS-CoV-2 mRNA vaccine-elicited germinal center B cells for neutralizing activity against the WA1/2020 D614G SARS-CoV-2 strain and variants of concern.

[EMBO Journal] Researchers immunized wild-type mice with insulin as a common self-antigen and monitored diabetes symptoms as a measure for autoimmune disease.

[Blood Cancer Journal] The authors found that interleukin-10 receptor (IL-10R) was overexpressed in most acute myeloid luekemia cells, and played an important role in promoting the stemness of leukemia cells.

[Cell Death & Disease] Investigators suggested that the main role of Bim in hematopoietic cells was the neutralization of Mcl-1, identified a number of likely molecular events during the maintenance of survival and the induction of apoptosis in mouse hematopoietic progenitor cells, and provided data on the regulation of expression and importance of these proteins during differentiation along the B cell lineage.

[npj Precision Oncology] Using in vitro models of JAK2r B-ALL, JAK2 p.G993A conferred resistance to six type-I JAK inhibitors and the type-II JAK inhibitor, CHZ-868.