Bcl-2

[International Journal of Cardiology] Researchers revealed that programmed cell death 5 (Pdcd5) deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.

[Phytotherapy Research] Researchers explored the apoptotic mechanism of Moracin D in prostate cancer cells in association with peroxisome proliferator-activated receptor gamma (PPAR-γ)-related signaling involved in lipid metabolism.

[Cell Death Discovery] The authors indicated that RCAN1.4 expression was impaired both in unilateral ureteral obstruction-induced renal fibrosis in vivo and TGF-β1-induced renal fibrosis in vitro. However, knocking in of RCAN1.4 suppressed the production of ECM both in vivo and in vitro.

[Cell Death & Disease] Scientists focused on the BCL-2 specific inhibitor venetoclax and its effects following short-term and long-term BCL-2 blockade on T cell subsets.

[Archiv Der Pharmazie] Investigators explored the mechanisms of action of alsevirone in prostate cancer in vitro and in vivo: CYP17A1 inhibition, cytotoxic, apoptotic, and antitumor effects compared with abiraterone.

[Metallomics] Researchers found that maternal selenium (Se) deficiency decreased placental Se concentration and expressions of some antioxidant selenoproteins.