CD69

[Stem Cell Reports] Investigators found that MSCs did not influence the proliferation of mucosal-associated invariant (TMAIT) cells but strikingly induced an activated phenotype with an increased expression of CD69, TNF-α, IFN-γ, and granzyme B.

[Mucosal Immunology] Researchers investigated the maturation of the CD8+ T cell compartment in human fetal, infant and adult intestinal tissues. CD8+ T cells exhibiting a memory phenotype were already detected in fetal intestines and increased after birth.

[Nature] Researchers showed that the concentration of sphingosine 1-phosphate (S1P) increased in lymph nodes during an immune response.

[Cancer Immunology Research] Researchers found that tumor-infiltrating CD8+ T cells initially expressed CD49b, gained CD49a, and then lost CD49b over the course of tumor outgrowth.

[Cell Reports Medicine] Persons with HIV and diabetes have a high proportion of CX3CR1+ GPR56+ CD57+ (C-G-C+) CD4+ T cells in adipose tissue, a subset of which are cytomegalovirus specific, whereas individuals with diabetes but without HIV have predominantly CD69+ CD4+ T cells.

[Leukemia] Scientists designed an alternative engager molecule, a bispecific antibody that could simultaneously bind to the Vγ9 chain of the Vγ9Vδ2+ γδ T cell receptor and to AML target antigen, CD123, to selectively recruit Vγ9+ γδ T cells rather than pan T cells to target AML blasts.