CD8

[Nature Communications] The authors showed that despite a significant reduction in peripheral effector Treg cells, clinical responses are minimal in a cohort of patients with advanced CCR4-negative solid cancer in a Phase Ib study.

[Cell Reports] Researchers investigated immune-related targets of SOX10 and observed positive regulation of herpesvirus entry mediator and carcinoembryonic-antigen cell-adhesion molecule 1.

[Pediatric Research] Scientists evaluated the effect of hydroxyurea on immune profiles through a controlled prospective cohort study conducted in 30 children with sickle cell anemia and 30 healthy age-matched controls.

[Clinical infectious Diseases] The authors investigated cellular immune responses up to five years after infection in a cohort of 59 Middle East respiratory syndrome survivors by performing ELISPOT assay and intracellular cytokine staining after stimulation of peripheral blood mononuclear cells with synthetic viral peptides.

[Cell Reports] Investigators performed in vivo and in vitro CRISPR screens to systematically identify genes influencing CD8 T cell expansion.

[PLoS Pathogens] Investigators examined the effect of transient breakdown of the immunological tolerance induced by Treg-cell depletion on adaptive immune responses against administered SARS-CoV-2 antigen, spike protein 1.