Using the OT-I/WT model, we showed that antigen-specific CD8 T cells were partially deleted in recipients after platelet-targeted gene transfer.
[Molecular Therapy-Nucleic Acids]
Li, J., Chen, J., Schroeder, J. A., Hu, J., Williams, C. B., & Shi, Q. (2021). Platelet-targeted gene therapy induces robust immune tolerance even in a primed model via peripheral clonal deletion of antigen-specific CD4 and CD8 T cells and expansion of antigen-specific regulatory T cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.12.026 Cite
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