Cellular and Humoral Immune Responses Following SARS-CoV-2 mRNA Vaccination in Patients with Multiple Sclerosis on Anti-CD20 Therapy

The authors investigated induction of antigen-specific antibody, B cell and T cell responses longitudinally in patients with multiple sclerosis on anti-CD20 antibody monotherapy compared with healthy controls after BNT162b2 or mRNA-1273 mRNA vaccination.
[Nature Medicine]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation

Analysis of fresh tumor samples from clear cell renal cell carcinoma patients unraveled the presence of a high frequency of tumor-infiltrating PD-L1+ natural killer (NK cells), suggesting that these NK cells might exhibit immunoregulatory functions.
[Frontiers in Immunology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Innate Immune Detection of Lipid Oxidation as a Threat Assessment Strategy

The authors highlight emerging functions of oxidized phosphocholines in dendritic cells and macrophages that drive unique inflammasome and migratory activities and hypermetabolic states.
[Nature Reviews Immunology]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

High-Dose Vitamin C Synergizes with Oncolytic Adenoviruses against Tumor by Enhancing Immunogenic Tumor Cell Death and Reprogramming Tumor Immune Microenvironment

The authors explored whether high-dose vitamin C (VitC) in combination with oncolytic adenoviruses exhibited a synergistic antitumor effect. Combination therapy with high-dose VitC and oncolytic adenoviruses significantly increased the number of T cells in the tumor microenvironment and promoted the activation of T cells.
[Molecular Therapy]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Conventional Type I Dendric Cells Maintain a Reservoir of Proliferative Tumor-Antigen Specific TCF-1+ CD8+ T Cells in Tumor-Draining Lymph Nodes

In tumors, a subset of CD8+ T cells expressing the transcription factor TCF-1 drives the response to immune checkpoint blockade. Scientists examined the mechanisms that maintain these cells in an autochthonous model of lung adenocarcinoma.
[Immunity]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

The Petroleum Ether Extract of Brassica rapa L. Induces Apoptosis of Lung Adenocarcinoma Cells via the Mitochondria-Dependent Pathway

The effects and pharmacological mechanisms of BRPS on the treatment of lung cancer were investigated both in vitro and in vivo.
[Food & Function]
[zotpress userid=” items=’9UU4TDCC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

A Randomized Phase II Trial of Idiotype Vaccination and Adoptive Autologous T Cell Transfer in Multiple Myeloma Patients

In this randomized, Phase II trial, eligible patients received either the control or idiotype-keyhole limpet hemocyanin vaccine, an auto-transplant, vaccine-specific co-stimulated T cells expanded ex vivo, and two booster doses of the assigned vaccine.
[Blood]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Ectopic Activation of the miR-200c–EpCAM Axis Enhances Antitumor T Cell Responses in Models of Adoptive Cell Therapy

Investigators found that ectopic expression of microRNA-200c markedly enhanced the antitumor activity of CD8+ cytotoxic T lymphocytes during adoptive cell therapy in multiple mouse models.
[Science Translational Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

A Small-Molecule SUMOylation Inhibitor Activates Antitumor Immune Responses and Potentiates Immune Therapies in Preclinical Models

Ex vivo treatment of mouse and human dendritic cells promoted their IFN1-dependent activation, and vaccination studies in mice demonstrated stimulation of antigen cross-presentation and T cell priming in vivo.
[Science Translational Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Attenuation of Peripheral Serotonin Inhibits Tumor Growth and Enhances Immune Checkpoint Blockade Therapy in Murine Tumor Models

Serotonin enhanced expression of PD-L1 on mouse and human cancer cells in vitro via serotonylation, which is the formation of covalent bonds between glutamine residues and serotonin, resulting in activation of small G proteins.
[Science Translational Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Low-Dose mRNA-1273 COVID-19 Vaccine Generates Durable Memory Enhanced by Cross-Reactive T Cells

Vaccine-specific CD4+ T cell, CD8+ T cell, binding antibody, and neutralizing antibody responses to the 25-μg Moderna mRNA-1273 vaccine were examined over seven months post-immunization.
[Science]
[zotpress userid=’6445218′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share
Share