[Nature Communications] Investigators comprehensively analyzed peripheral blood and/or synovial fluid samples from 20 patients with immune-related adverse events, including arthritis, and unmasked a prominent Th1-CD8+ T cell axis in both blood and inflamed joints.
[Science] Researchers demonstrated mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with systemic lupus erythematosus.
[Cancer Cell International] The authors indicated a relationship between synaptosome associated protein 25 (SNAP25) expression and prostate cancer, demonstrating that SNAP25 was a potential prognostic biomarker due to its vital role in immune infiltration.
[Open Biology] Scientists developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.
[Science Advances] To determine the potential for viral adaptation to T cell responses, scientists probed the full influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in the context of an experimental T cell-based vaccine, an H5N1-based viral vectored vaccinia vaccine Wyeth/IL-15/5Flu, versus the current standard-of-care.