Tag Archives: CD8

Platelet-Targeted Gene Therapy Induces Robust Immune Tolerance Even in a Primed Model via Peripheral Clonal Deletion of Antigen-Specific CD4 and CD8 T Cells and Expansion of Antigen-Specific Regulatory T Cells

Using the OT-I/WT model, we showed that antigen-specific CD8 T cells were partially deleted in recipients after platelet-targeted gene transfer.
[Molecular Therapy-Nucleic Acids]
Li, J., Chen, J., Schroeder, J. A., Hu, J., Williams, C. B., & Shi, Q. (2021). Platelet-targeted gene therapy induces robust immune tolerance even in a primed model via peripheral clonal deletion of antigen-specific CD4 and CD8 T cells and expansion of antigen-specific regulatory T cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.12.026 Cite
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NF-ÎşB-Inducing Kinase Maintains T Cell Metabolic Fitness in Antitumor Immunity

Scientists showed that deficiency in NF-ÎşB-inducing kinase (NIK) impaired glycolysis induction, rendering CD8+ effector T cells hypofunctional in the tumor microenvironment.
[Nature Immunology]
NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity | Nature Immunology. (n.d.). Retrieved January 5, 2021, from https://www.nature.com/articles/s41590-020-00829-6 Cite
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Epicutaneous Immunization with Modified Vaccinia Ankara Viral Vectors Generates Superior T Cell Immunity against a Respiratory Viral Challenge

Comparisons of skin scarification with intradermal, subcutaneous, or intramuscular routes showed that MVAOVA skin scarification-generated T cells were both more abundant and transcriptionally unique.
[npj Vaccines]
Pan, Y., Liu, L., Tian, T., Zhao, J., Park, C. O., Lofftus, S. Y., Stingley, C. A., Yan, Y., Mei, S., Liu, X., & Kupper, T. S. (2021). Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge. Npj Vaccines, 6(1), 1–9. https://doi.org/10.1038/s41541-020-00265-5 Cite
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Memory-Like HCV-Specific CD8+ T Cells Retain a Molecular Scar after Cure of Chronic HCV Infection

Researchers report a progenitor–progeny relationship between memory-like and terminally exhausted hepatitis C virus-specific CD8+ T cells via an intermediate subset.
[Nature Immunology]
Hensel, N., Gu, Z., Sagar, Wieland, D., Jechow, K., Kemming, J., Llewellyn-Lacey, S., Gostick, E., Sogukpinar, O., Emmerich, F., Price, D. A., Bengsch, B., Boettler, T., Neumann-Haefelin, C., Eils, R., Conrad, C., Bartenschlager, R., Grün, D., Ishaque, N., … Hofmann, M. (2021). Memory-like HCV-specific CD8 + T cells retain a molecular scar after cure of chronic HCV infection. Nature Immunology, 1–11. https://doi.org/10.1038/s41590-020-00817-w Cite
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Liver Metastasis Restrains Immunotherapy Efficacy via Macrophage-Mediated T Cell Elimination

Researchers report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical models. Patients with liver metastases derive limited benefit from immunotherapy independent of other established biomarkers of response.
[Nature Medicine]
Yu, J., Green, M. D., Li, S., Sun, Y., Journey, S. N., Choi, J. E., Rizvi, S. M., Qin, A., Waninger, J. J., Lang, X., Chopra, Z., El Naqa, I., Zhou, J., Bian, Y., Jiang, L., Tezel, A., Skvarce, J., Achar, R. K., Sitto, M., … Zou, W. (2021). Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-020-1131-x Cite
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The Mutational Load and a T-Cell Inflamed Tumor Phenotype Identify Ovarian Cancer Patients Rendering Tumor-Reactive T Cells from PD-1+ Tumor-Infiltrating Lymphocytes

Tumor-reactive tumor-infiltrating lymphocytes were detected in half of patients and were exclusively present in cells derived from the PD-1+ fraction.
[British Journal of Cancer]
Salas-Benito, D., Conde, E., Tamayo-Uria, I., Mancheño, U., Elizalde, E., Garcia-Ros, D., Aramendia, J. M., Muruzabal, J. C., Alcaide, J., Guillen-Grima, F., Minguez, J. A., Amores-Tirado, J., Gonzalez-Martin, A., Sarobe, P., Lasarte, J. J., Ponz-Sarvise, M., De Andrea, C. E., & Hervas-Stubbs, S. (2021). The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1 + tumour-infiltrating lymphocytes. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01218-4 Cite
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Skin T Cells Maintain Their Diversity and Functionality in the Elderly

Researchers assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries.
[Communications Biology]
Koguchi-Yoshioka, H., Hoffer, E., Cheuk, S., Matsumura, Y., Vo, S., Kjellman, P., Grema, L., Ishitsuka, Y., Nakamura, Y., Okiyama, N., Fujisawa, Y., Fujimoto, M., Eidsmo, L., Clark, R. A., & Watanabe, R. (2021). Skin T cells maintain their diversity and functionality in the elderly. Communications Biology, 4(1), 1–8. https://doi.org/10.1038/s42003-020-01551-7 Cite
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Labeling and Tracking of Immune Cells in Ex Vivo Human Skin

The authors developed an ex vivo imaging approach in which fresh skin biopsies were mounted and then labeled with nanobodies or antibodies against cell surface markers on tissue-resident memory CD8+ T cells, other immune cells of interest, or extracellular tissue components.
[Nature Protocols]
Dijkgraaf, F. E., Toebes, M., Hoogenboezem, M., Mertz, M., Vredevoogd, D. W., Matos, T. R., Teunissen, M. B. M., Luiten, R. M., & Schumacher, T. N. (2020). Labeling and tracking of immune cells in ex vivo human skin. Nature Protocols, 1–21. https://doi.org/10.1038/s41596-020-00435-8 Cite
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An IL-2-Grafted Antibody Immunotherapy with Potent Efficacy against Metastatic Cancer

Researchers present a second-generation CD122-biased interleukin-2 (IL-2), developed by splitting and permanently grafting unmutated human IL-2 (hIL-2) to its antigen-binding groove on the anti-hIL-2 monoclonal antibody NARA1, thereby generating NARA1leukin.
[Nature Communications]
Sahin, D., Arenas-Ramirez, N., Rath, M., Karakus, U., Hümbelin, M., van Gogh, M., Borsig, L., & Boyman, O. (2020). An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer. Nature Communications, 11(1), 6440. https://doi.org/10.1038/s41467-020-20220-1 Cite
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Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy

The authors performed single-cell RNA sequencing on kidneys and CD14+ peripheral blood mononuclear cells collected from IgA nephropathy (IgAN) and normal samples. In IgAN, upregulation of JCHAIN in mesangial cells provided insight into the trigger mechanism for the dimerization and deposition of IgA1 in situ.
[Cell Reports]
Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy: Cell Reports. (n.d.). Retrieved January 5, 2021, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31514-X Cite
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Mechanism of EBV Inducing Anti-Tumor Immunity and Its Therapeutic Use

Researchers showed that expression of the Epstein–Barr virus signaling protein LMP1 in B cells provokes T cell responses to multiple tumor-associated antigens.
[Nature]
Mechanism of EBV inducing anti-tumour immunity and its therapeutic use | Nature. (n.d.). Retrieved January 5, 2021, from https://www.nature.com/articles/s41586-020-03075-w Cite
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