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Distinct Molecular and Immune Hallmarks of Inflammatory Arthritis Induced by Immune Checkpoint Inhibitors for Cancer Therapy

[Nature Communications] Investigators comprehensively analyzed peripheral blood and/or synovial fluid samples from 20 patients with immune-related adverse events, including arthritis, and unmasked a prominent Th1-CD8+ T cell axis in both blood and inflamed joints.

Replicative History Marks Transcriptional and Functional Disparity in the CD8+ T Cell Memory Pool

[Nature Immunology] Researchers developed a genetic-tracing approach, termed the DivisionRecorder, that reported the extent of past proliferation of cell pools in vivo.

Single-Cell RNA-Seq Reveals Cell Type-Specific Molecular and Genetic Associations to Lupus

[Science] Researchers demonstrated mux-seq as a systematic approach to characterize cellular composition, identify transcriptional signatures, and annotate genetic variants associated with systemic lupus erythematosus.

SNAP25 Is a Potential Prognostic Biomarker for Prostate Cancer

[Cancer Cell International] The authors indicated a relationship between synaptosome associated protein 25 (SNAP25) expression and prostate cancer, demonstrating that SNAP25 was a potential prognostic biomarker due to its vital role in immune infiltration.

Modeling T Cell Immunity against Hepatitis C Virus with Liver Organoids in a Microfluidic Coculture System

[Open Biology] Scientists developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.

Next-Generation T Cell-Activating Vaccination Increases Influenza Virus Mutation Prevalence

[Science Advances] To determine the potential for viral adaptation to T cell responses, scientists probed the full influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in the context of an experimental T cell-based vaccine, an H5N1-based viral vectored vaccinia vaccine Wyeth/IL-15/5Flu, versus the current standard-of-care.