Using the OT-I/WT model, we showed that antigen-specific CD8 T cells were partially deleted in recipients after platelet-targeted gene transfer.
[Molecular Therapy-Nucleic Acids]
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Li, J., Chen, J., Schroeder, J. A., Hu, J., Williams, C. B., & Shi, Q. (2021). Platelet-targeted gene therapy induces robust immune tolerance even in a primed model via peripheral clonal deletion of antigen-specific CD4 and CD8 T cells and expansion of antigen-specific regulatory T cells. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.12.026 Cite
Scientists showed that deficiency in NF-κB-inducing kinase (NIK) impaired glycolysis induction, rendering CD8+ effector T cells hypofunctional in the tumor microenvironment.
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Comparisons of skin scarification with intradermal, subcutaneous, or intramuscular routes showed that MVAOVA skin scarification-generated T cells were both more abundant and transcriptionally unique.
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Pan, Y., Liu, L., Tian, T., Zhao, J., Park, C. O., Lofftus, S. Y., Stingley, C. A., Yan, Y., Mei, S., Liu, X., & Kupper, T. S. (2021). Epicutaneous immunization with modified vaccinia Ankara viral vectors generates superior T cell immunity against a respiratory viral challenge. Npj Vaccines, 6(1), 1–9. https://doi.org/10.1038/s41541-020-00265-5 Cite
Researchers report a progenitor–progeny relationship between memory-like and terminally exhausted hepatitis C virus-specific CD8+ T cells via an intermediate subset.
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Hensel, N., Gu, Z., Sagar, Wieland, D., Jechow, K., Kemming, J., Llewellyn-Lacey, S., Gostick, E., Sogukpinar, O., Emmerich, F., Price, D. A., Bengsch, B., Boettler, T., Neumann-Haefelin, C., Eils, R., Conrad, C., Bartenschlager, R., Grün, D., Ishaque, N., … Hofmann, M. (2021). Memory-like HCV-specific CD8 + T cells retain a molecular scar after cure of chronic HCV infection. Nature Immunology, 1–11. https://doi.org/10.1038/s41590-020-00817-w Cite
Researchers report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical models. Patients with liver metastases derive limited benefit from immunotherapy independent of other established biomarkers of response.
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Yu, J., Green, M. D., Li, S., Sun, Y., Journey, S. N., Choi, J. E., Rizvi, S. M., Qin, A., Waninger, J. J., Lang, X., Chopra, Z., El Naqa, I., Zhou, J., Bian, Y., Jiang, L., Tezel, A., Skvarce, J., Achar, R. K., Sitto, M., … Zou, W. (2021). Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-020-1131-x Cite
Tumor-reactive tumor-infiltrating lymphocytes were detected in half of patients and were exclusively present in cells derived from the PD-1+ fraction.
[British Journal of Cancer]
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Salas-Benito, D., Conde, E., Tamayo-Uria, I., Mancheño, U., Elizalde, E., Garcia-Ros, D., Aramendia, J. M., Muruzabal, J. C., Alcaide, J., Guillen-Grima, F., Minguez, J. A., Amores-Tirado, J., Gonzalez-Martin, A., Sarobe, P., Lasarte, J. J., Ponz-Sarvise, M., De Andrea, C. E., & Hervas-Stubbs, S. (2021). The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1 + tumour-infiltrating lymphocytes. British Journal of Cancer, 1–12. https://doi.org/10.1038/s41416-020-01218-4 Cite
Researchers assessed T-cell density, diversity, and function in individuals of various ages to study the immunologic effects of aging on human skin from two different countries.
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Koguchi-Yoshioka, H., Hoffer, E., Cheuk, S., Matsumura, Y., Vo, S., Kjellman, P., Grema, L., Ishitsuka, Y., Nakamura, Y., Okiyama, N., Fujisawa, Y., Fujimoto, M., Eidsmo, L., Clark, R. A., & Watanabe, R. (2021). Skin T cells maintain their diversity and functionality in the elderly. Communications Biology, 4(1), 1–8. https://doi.org/10.1038/s42003-020-01551-7 Cite
The authors developed an ex vivo imaging approach in which fresh skin biopsies were mounted and then labeled with nanobodies or antibodies against cell surface markers on tissue-resident memory CD8+ T cells, other immune cells of interest, or extracellular tissue components.
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Researchers present a second-generation CD122-biased interleukin-2 (IL-2), developed by splitting and permanently grafting unmutated human IL-2 (hIL-2) to its antigen-binding groove on the anti-hIL-2 monoclonal antibody NARA1, thereby generating NARA1leukin.
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The authors performed single-cell RNA sequencing on kidneys and CD14+ peripheral blood mononuclear cells collected from IgA nephropathy (IgAN) and normal samples. In IgAN, upregulation of JCHAIN in mesangial cells provided insight into the trigger mechanism for the dimerization and deposition of IgA1 in situ.
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Single-Cell Transcriptomics Reveal Immune Mechanisms of the Onset and Progression of IgA Nephropathy: Cell Reports. (n.d.). Retrieved January 5, 2021, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31514-X Cite
Researchers showed that expression of the Epstein–Barr virus signaling protein LMP1 in B cells provokes T cell responses to multiple tumor-associated antigens.
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