Next-Generation T Cell-Activating Vaccination Increases Influenza Virus Mutation Prevalence

To determine the potential for viral adaptation to T cell responses, scientists probed the full influenza virus genome by next-generation sequencing directly ex vivo from infected mice, in the context of an experimental T cell-based vaccine, an H5N1-based viral vectored vaccinia vaccine Wyeth/IL-15/5Flu, versus the current standard-of-care.