CD8

[Cancer Gene Therapy] In the MC38 tumor model, combined administration of plasmids encoding IL-12 and an anti-PD-1 antibody induced significant anti-tumor responses, yet similar to the monotherapies.

[PLoS Neglected Tropical Diseases] Scientists investigated the expression of FOXP3+ Treg cells in leprosy skin lesions and to correlate their clinical forms, laboratory characteristics, and the immune reconstitution syndrome in HIV-leprosy co-infection.

[Cell Death Discovery] The abundance of myeloid-derived suppressor cells in the tumour microenvironment was associated with therapeutic efficacy and disease outcome. Scientists analyzed the changes in the immune contexture in response to the carbon ion treatment.

[Cancer Cell] Investigators showed that tumor-specific CD8+ tumor-infiltrating lymphocytes accumulated in tumor islets, where they engage antigen and upregulate PD-1, which restrained their functions.

[Heliyon] Scientists reported a comprehensive pattern of Hopx expression in multiple types of immune cells under steady state conditions.

[Nature] The authors identified the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and secreted by activated B cells and plasma cells.