CD8

[Nature Communications] The authors utilized an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2.

[Digestive and Liver Disease] Scientists summarize the current knowledge of how different crosstalk between liver sinusoidal endothelial cells and other liver cells, including hepatocytes, hepatic stellate cells, macrophoges, immune cells in liver and extra cellular matrix contribute to the physiological function and the progrssion from liver fibrosis to cirrhosis, or even to hepatocellular carcinoma.

[Cancer Cell] Using multiple preclinical models of neoantigen-expressing pancreatic adenocarcinoma (PDAC), scientists demonstrated that intratumoral neoantigen-specific CD8+ T cells adopted multiple states of dysfunction, resembling those in tumor-infiltrating lymphocytes of PDAC patients.

[Nature Immunology] The authors describe the history of research on bystander CD8+ T cell activation as well as evidence of bystander activation. They also discuss the mechanisms and immunopathological roles of bystander activation in various microbial infections.

[Nature Immunology] Scientists confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specific CD8+ T cells in human hepatitis C virus (HCV) infection before and after treatment.

[Nature Communications] Scientists reported SARS-CoV-2 specific T cell responses in infected adults and children and find that the acute and memory CD4+ T cell responses to structural SARS-CoV-2 proteins increase with age, whereas CD8+ T cell responses increase with time post-infection.