CXCL10

[Proceedings of the National Academy of Sciences of the United States of America] In constitutive GPR182-deficient mice, as well as after induced endothelium-specific loss of GPR182, investigators found significant increases in the plasma levels of CXCL10, CXCL12, and CXCL13.

[Scientific Reports] To better understand the mechanistic effect cromolyn has in slowing down or halting the neuroinflammatory response associated with Alzheimer’s Disease progression, the authors tested the effect of cromolyn to dampen the inflammatory response in the human HMC3 microglia cell line.

[Cell Reports] Investigators showed that cyclin-dependent kinases 4 and 6 (CDK4/6i) could enhance efficacy of T cell-based therapies, such as adoptive T cell transfer or T cell-activating antibodies anti-OX40/anti-4-1BB, in murine breast cancer models.

[Scientific Reports] A progressive and consistent reduction of tumor growth was observed when gal-9-KO cells were subjected to serial transplantations into syngeneic mice.

[Nature Immunology] Scientists developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate.

[International Immunopharmacology] Human umbilical cord mesenchymal stem cells were used to deliver reovirus using in vitro and in vivo models.