Scientists developed a platform to quantify cell location in three dimensions to determine the spatial requirements that direct T cell fate.
[Nature Immunology]
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Duckworth, B. C., Lafouresse, F., Wimmer, V. C., Broomfield, B. J., Dalit, L., Alexandre, Y. O., Sheikh, A. A., Qin, R. Z., Alvarado, C., Mielke, L. A., Pellegrini, M., Mueller, S. N., Boudier, T., Rogers, K. L., & Groom, J. R. (2021). Effector and stem-like memory cell fates are imprinted in distinct lymph node niches directed by CXCR3 ligands. Nature Immunology, 1–15. https://doi.org/10.1038/s41590-021-00878-5 Cite