CXCR3

[Immunity] Scientists found that skin CD4+ tissue-resident memory T cells were depleted after HIV infection and replenished only upon early antiretroviral therapy initiation.

[Cell Reports] The authors suggested that infiltrative monocytes promoted fibrogenesis in nonalcoholic fatty liver disease via ADA2-mediated autocrine/paracrine signaling culminating in enhanced PDGF-B production.

[Cancer Immunology Research] Researchers demonstrated that the anti-CD137 agonist urelumab can overcome TGFβ-mediated inhibition of human NK-cell proliferation and antitumor function.

[Anti-Cancer Drugs] Subcutaneous A549 lung cancer and murine Lewis lung carcinoma (LLC) models were constructed, which were further intravenously injected with platinum-based drugs or concomitant administrated with anti-PD-1 antibody and or anti-NKG2D antibody.

[PLOS Pathogens] The authors reported that CXCR3-dependent recruitment of Ly6C+ Th1 effector cells was indispensable for concomitant immunity and acute cell-phagocyte interactions were critical to prevent the establishment of a permissive pathogen niche.

[Cell Reports] Researchers applied mass cytometry and uncover decidual-like natural killer cell subpopulations in newly diagnosed high-grade serous carcinoma samples that correlated with both tumor and transitioning epithelial-mesenchymal cell abundance.