EGFR

[International Journal of Radiation Oncology Biology Physics] Researchers presented novel mechanistic evidence relating to signaling pathways with DNA damage responses in epidermal growth factor receptor-mutated glioblastoma multiforme.

[Journal of the American Chemical Society] Researchers demonstrated approximately 3-fold higher doxorubicin internalization in inflammatory breast cancer cells compared to healthy breast epithelial cells, leading to targeted cell death at concentrations below the IC50 of free doxorubicin.

[Science Advances] In this proof-of-concept study, the authors successfully established organoids from seven chordoma tumor samples obtained from five patients presenting with tumors in different sites and stages of disease.

[Cancer Letters] The authors investigated the role of the tumor stem cell marker DCLK1 in epithelial growth factor receptor-tyrosine kinase inhibitor resistance of lung adenocarcinoma.

[Oncogene] Scientists demonstrate that activated T cells armed with anti-CD3 x anti-EGFR bispecific antibody increases tumor infiltrating lymphocytes and mediate anti-tumor cytotoxicity while decreasing tumor cell viability.

[Nature Communications] Scientists used quantitative fluorescence and electron microscopy to reveal a mechanism where flat clathrin lattices partitioned and activated growth factor signals via a coordinated response that involved crosstalk between epidermal growth factor receptor and the adhesion receptor β5-integrin.