EMT

[Molecular Cancer Research] Researchers analyzed MIB1 expression levels in tumor samples and performed gain- and loss-of-function studies in cell lines to investigate potential roles of MIB1 in epithelial-to-mesenchymal transition, cell migration and cell survival.

[FEBS Journal] Scientists reported on the epidermal growth factor receptor (EGFR)-estrogen receptor beta (ERβ) functional relationship in connection to the aggressiveness and cancer stem cell-like characteristics of triple-negative breast cancer cells.

[Cell Death Discovery] Scientists demonstrated that MSCs derived from oral squamous cell carcinoma (OSCC) promoted the metastasis of OSCC cells by transwell assay and animal models through epithelial to mesenchymal transition.

[Oncogene] Genetic deletion of all miR-200s in the human gastric cancer cell lines induced potent morphological alterations, G1/S cell cycle arrest, increased senescence-associated β-galactosidase activity, and aberrant metabolism, collectively resembling the senescent phenotype.

[Oncogene] Gain- and loss-of-function studies demonstrate that phosphoenolpyruvate carboxykinase 1 (PCK1) suppressed hepatocellular carcinoma metastasis in vitro and in vivo. Specifically, lysine acetyltransferase 5 (KAT5) was highly modified by O-GlcNAcylation in PCK1 knockout hepatoma cells.

[Breast Cancer Research] Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.